LH 846
Casein kinase 1d inhibitor
Product Specifications
Background
LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm.
CAS Number
639052-78-1
Product Name Alternative
LH846, LH-846, N- (5-Chloro-6-methyl-2-benzothiazolyl) benzeneacetamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
≥98% (HPLC)
Weight
0.025
Format
White to beige powder
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C16H13ClN2OS
Molecular Weight
316.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611.
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