BIBW 2992
EGFR, HER2 kinase inhibitor
Product Specifications
Background
BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.
CAS Number
850140-72-6
Product Name Alternative
Afatinib, N-[4-[ (3-chloro-4-fluorophenyl) amino]-7-[[ (3S) -tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4- (dimethylamino) -2-butenamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>99%
Weight
0.025
Format
Crystalline solid
Solubility
Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.
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