Axitinib
VEGFR kinase inhibitor
Product Specifications
Background
Axitinib is a potent and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. It has also been shown to inhibit PDGFR-β and c-Kit.
CAS Number
319460-85-0
Product Name Alternative
AG-013736, N-Methyl-2- ((3- ((1E) -2- (pyridin-2-yl) ethenyl) -1H-indazol-6-yl) sulfanyl) benzamide, N-Methyl-[[3[ (1E) -2- (2-pyridinyl) ethenyl]-1H-indazol-6-yl]thio]-benzamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cardiovascular System | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.01
Format
White to tan powder
Solubility
Soluble to 25 mM in DMSO
Molecular Formula
C22H18N4OS
Molecular Weight
386.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hu-Lowe D.D., et al. (2008) Clin. Cancer Res: J. Am. Ass. Cancer Res. 14(22): 7272–7283.
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