AG 494
EGFR kinase inhibitor
Product Specifications
Background
AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.
CAS Number
133550-35-3
Product Name Alternative
AG-494, (E) -2-Cyano-3- (3,4-dihydroxyphenyl) -N-phenyl-2-propenamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.05
Format
Yellow solid
Solubility
Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Molecular Formula
C16H12N2O3
Molecular Weight
280.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457.
2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.
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