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AG 494

EGFR kinase inhibitor

Product Specifications

Background

AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.

Product Name Alternative

AG-494, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (TLC)

Weight

0.01

Format

Yellow solid

Solubility

Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)

Molecular Formula

C16H12N2O3

Molecular Weight

280.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.