ZM447439
Aurora B kinase inhibitor
Product Specifications
Background
ZM447439 is a potent and selective inhibitor of Aurora B kinase. ZM447439 induces cell growth arrest mid-way through mitosis, and therefore effectively activates apoptosis.
CAS Number
331771-20-1
Product Name Alternative
ZM 447439, N-[4-[[6-Methoxy-7-[3- (4-morpholinyl) propoxy]-4-quinazolinyl]amino]phenyl]benzamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC) ; NMR (Conforms)
Weight
0.01
Format
Orange solid
Solubility
May be dissolved in DMSO (50mg/mL)
Molecular Formula
C29H31N5O4
Molecular Weight
513.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669.
2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525.
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