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WHI P131

JAK3 kinase inhibitor

Product Specifications

Background

WHI P131 also known as Janex-1, is a reversible, potent, and specific inhibitor of JAK3. WHI P131 is cell permeable. It has been seen to inhibit glioblastoma cell adhesion and migration, as well as, thrombin-induced platelet aggregation.

CAS Number

202475-60-3

Product Name Alternative

WHI-P131, Janex 1, 4-​[ (6, ​7-​dimethoxy-​4-​quinazolinyl) amino]-​phenol

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98%

Weight

0.05

Format

White to off-white solid

Solubility

Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml)

Molecular Formula

C16H15N3O3

Molecular Weight

297.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582.

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