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Vatalanib Dihydrochloride

VEGFR Tyrosine Kinase Inhibitor

Product Specifications

Background

Vatalanib Dihydrochloride is an inhibitor of Flk, c-Kit and PDGFR-β. It has been shown to inhibit VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival.

CAS Number

212141-51-0

Product Name Alternative

N- (4-Chlorophenyl) -4- (4-pyridinylmethyl) -1-phthalazinamine dihydrochloride

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cardiovascular System | Cancer Growth Inhibitors | Growth Factor Receptor Inhibitors

Purity

≥96%

Weight

0.01

Format

Solid

Solubility

Soluble in DMSO (30 mg/ml), ethanol (10 mg/ml) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/ml )

Molecular Formula

C20H17Cl3N4

Molecular Weight

419.7

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Herbst R.S., Heymach J.V., O'Reilly M. S., Onn A., & Ryan A.J. (2007) Expert Opin. Invest. Drugs. 16(2): 239–249.

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