STO 609
CAMKK kinase inhibitor
Product Specifications
Background
STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable.
CAS Number
52029-86-4
Product Name Alternative
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.005
Format
Yellow solid
Solubility
Soluble in DMSO (10 mg/ml)
Molecular Formula
C21H14N2O5
Molecular Weight
374.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818.
2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364.
3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.
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