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STO 609

CAMKK kinase inhibitor

Product Specifications

Background

STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable.

CAS Number

52029-86-4

Product Name Alternative

7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98% (TLC)

Weight

0.025

Format

Yellow solid

Solubility

Soluble in DMSO (10 mg/ml)

Molecular Formula

C21H14N2O5

Molecular Weight

374.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818. 2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364. 3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.

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