SB203580
P38 MAP kinase inhibitor
Product Specifications
Background
SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.
CAS Number
152121-47-6
Product Name Alternative
4- (4-Fluorophenyl) -2- (4-methylsulfinylphenyl) -5- (4-pyridyl) 1H-imidazole
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.005
Format
White to off-white powder
Solubility
Soluble in DMSO (50 mg/ml)
Molecular Formula
C21H16FN3OS
Molecular Weight
377.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054.
2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589.
3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.
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