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SB203580

p38 MAP kinase inhibitor

Product Specifications

Background

SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.

Product Name Alternative

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (HPLC)

Weight

0.025

Format

White to off-white powder

Solubility

Soluble in DMSO (50 mg/ml)

Molecular Formula

C21H16FN3OS

Molecular Weight

377.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.