SB202190
P38 MAP kinase inhibitor
Product Specifications
Background
SB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.
CAS Number
152121-30-7
Product Name Alternative
FHPI, 4- (4-Fluorophenyl) -2- (4-hydroxyphenyl) -5- (4-pyridyl) -1H-imidazole
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.025
Format
Pale yellow solid
Solubility
Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate
Molecular Formula
C20H14FN3O
Molecular Weight
331.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420.
2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.
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