PX 866
PI 3-Kinase inhibitor
Product Specifications
Background
PX 866 is a wortmannin derivative that inhibits purified phosphoinositide (PtdIns)-3-kinase and. PX 866 has been shown to inhibit tumor growth by blocking the PI 3-kinase pathway and cell motility.
CAS Number
502632-66-8
Product Name Alternative
(1E, 4S, 4aR, 5R, 6aS, 9aR) -5- (acetyloxy) -1-[ (di-2-propen-1-ylamino) methylene]-4, 4a, 5, 6, 6a, 8, 9, 9a-octahydro-11-hydroxy-4- (methoxymethyl) -4a, 6a-dimethyl-cyclopenta[5, 6]naphtho[1, 2-c]pyran-2, 7, 10 (1H) -trione
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98%
Weight
0.005
Format
Crystalline solid
Solubility
Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water
Molecular Formula
C29H35NO8
Molecular Weight
525.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ihle N.T., et al. (2004). Mol. Cancer. Ther. 3(7): 763–772. 2. Gwak H.S., et al. (2011). Int. J. Cancer. 128(4): 787–796.
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