PP1
Src kinase inhibitor
Product Specifications
Background
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
Product Name Alternative
1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
UNSPSC
41116105
Source
Synthetic
Purity
≥ 98% (TLC)
Weight
0.025
Format
Tan solid
Solubility
Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Molecular Formula
C16H19N5
Molecular Weight
281.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
CAS Number
172889-26-8
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