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Midostaurin

Kinase inhibitor

Product Specifications

Background

Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.

CAS Number

120685-11-2

Product Name Alternative

4'-N-Benzoyl-staurosporine, Midostaurin, CGP 41251

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98% (TLC)

Weight

0.005

Format

White to off-white powder

Solubility

Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)

Molecular Formula

C35H30N4O4

Molecular Weight

570.6

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28. 2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110. 3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.

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