Midostaurin
Kinase inhibitor
Product Specifications
Background
Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.
CAS Number
120685-11-2
Product Name Alternative
4'-N-Benzoyl-staurosporine, PKC-412, CGP 41251
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.001
Format
White to off-white powder
Solubility
Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml)
Molecular Formula
C35H30N4O4
Molecular Weight
570.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28.
2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110.
3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.
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