Picropodophyllotoxin
IGF1R inhibitor
Product Specifications
Background
Picropodophyllotoxin is an inhibitor of insulin-like growth factor 1 receptor (IGF1R). Specifically, it inhibits IGF1R autophosphorylation. It has also been seen to increases the fraction of cells in the G2/M phase, reduce pAKT and pERK1/2, and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines.
CAS Number
477-47-4
Product Name Alternative
Picropodophyllin, NSC 36407, PPP, (5R,5aS,8aR,9R) -5,8,8a,9-Tetrahydro-9-hydroxy-5- (3,4,5-trimethoxyphenyl) -furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6 (5aH) -one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
≥96% (HPLC)
Weight
0.005
Format
White solid
Solubility
Soluble in DMSO (10 mg/ml, warm) or dimethyl formamide (25 mg/ml)
Molecular Formula
C22H22O8
Molecular Weight
414.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Girnita A., et al. (2004) Cancer Res. 64(1): 236–242. 2. Strömberg T., et al. (2006) Blood. 107(2): 669–678.
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