What is the catalog number for PD98059?

The catalog number for PD98059 is SIH-466-5MG.

What sizes are available for PD98059?

PD98059 is available in the following size(s): 5 mg.

PD98059 is currently made to order / not held in immediate stock. Contact us for lead time.

PD98059

MEK kinase inhibitor

Product Specifications

Background

PD98059 is a potent, selective and reversible inhibitor of mitogen-activated protein kinase kinase (MAPKK/ MEK-1) activation. Specifically, it binds to the inactive form of MAPKK, blocking its activation, causing inhibition of phosphorylation and the activation of MAP kinase. It has been shown to enhance self-renewal of embryonic stem cells. PD98059 is cell permeable inhibitor.

CAS Number

167869-21-8

Product Name Alternative

2- (2-Amino-3-methoxyphenyl) -4H-1-benzopyran-4-one, PD98059

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

>98% (HPLC) ; NMR (Conforms)

Weight

0.005

Format

Pale yellow solid

Solubility

May be dissolved in DMSO (6mg/mL)

Molecular Formula

C16H13NO3

Molecular Weight

267.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494. 2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032. 3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.