KT 5823
PKG kinase inhibitor
Product Specifications
Background
KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependently inhibit spontaneous apoptosis of neutrophils.
CAS Number
126643-37-6
Product Name Alternative
(9S,10R,12R) -2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.0001
Format
White solid
Solubility
Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml)
Molecular Formula
C29H25N3O5
Molecular Weight
495.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Murthy K.S., & Makhlouf G.M. (1995) Am J. Phys. 268(1 Pt 1): C171–180.
2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501.
3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.
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