KT 5823

PKG kinase inhibitor

Product Specifications

Background

KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependently inhibit spontaneous apoptosis of neutrophils.

Product Name Alternative

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (TLC)

Weight

0.0001

Format

White solid

Solubility

Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml)

Molecular Formula

C29H25N3O5

Molecular Weight

495.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Murthy K.S., & Makhlouf G.M. (1995) Am J. Phys. 268(1 Pt 1): C171–180. 2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501. 3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.