K252B

Kinase inhibitor

Product Specifications

Background

K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.

Product Name Alternative

(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (HPLC)

Weight

0.001

Format

White solid

Solubility

Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)

Molecular Formula

C26H19N3O5

Molecular Weight

453.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071. 2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969. 3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.