K252B

Kinase inhibitor

Product Specifications

Background

K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.

CAS Number

99570-78-2

Product Name Alternative

(9S, 10R, 12R) -2, 3, 9, 10, 11, 12-hexahydro-10-hydroxy-9-methyl-1-oxo-9, 12-epoxy-1H-diindolo[1, 2, 3-fg:3', 2', 1'-kl]pyrrolo[3, 4-i][1, 6]benzodiazocine-10-carboxylic acid

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98% (HPLC)

Weight

0.001

Format

White solid

Solubility

Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)

Molecular Formula

C26H19N3O5

Molecular Weight

453.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071. 2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969. 3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.