K252A
Kinase inhibitor
Product Specifications
Background
K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent autophosphorylation and activation of downstream effectors.
CAS Number
99533-80-9
Product Name Alternative
(9S,10R,12R) -2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Nonomuraea longicatena
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.001
Format
White solid
Solubility
Soluble to 25 mM in DMSO
Molecular Formula
C27H21N3O5
Molecular Weight
467.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885–4893.
2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.
3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.
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