GW5074
C-Raf1 kinase inhibitor
Product Specifications
Background
GW5074 is a potent and selective c-Raf1 kinase inhibitor. GW5074 shows ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW5074 has been shown to block low potassium induced cell death, as well as, prevent neurodegeneration. GW5074 is cell-permeable.
CAS Number
220904-83-6
Product Name Alternative
3- (3,5-Dibromo-4-hydroxybenzyliden) -5-iodo-1,3-dihydroindol-2-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.025
Format
Yellow to orange solid
Solubility
Soluble to 1 mM in ethanol and to 100 mM in DMSO
Molecular Formula
C15H8Br2INO2
Molecular Weight
520.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Chin P.C., et al. (2004) J. Neurochem. 90(3): 595–608.
2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226.
3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.
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