GW 441756
NGFR kinase inhibitor
Product Specifications
Background
GW 441756 is a potent and selective NGF receptor tyrosine kinase A (TrkA) inhibitor. Specifically, it is shown to block apoptosis and cell death induced by TrkA. GW-441756 displays > 100-fold selectivity over a range of other kinases.
CAS Number
504433-23-2
Product Name Alternative
1,3-Dihydro-3-[ (1-methyl-1H-indol-3-yl) methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>99 %
Weight
0.01
Format
Red solid
Solubility
Soluble to 15 mM in DMSO
Molecular Formula
C17H13N3O
Molecular Weight
275.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wood E.R., et al. (2004) Bioorganic & Med. Chem. Ltr. 14(4): 953–957. 2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.
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