GW2580
cFMS kinase inhibitor
Product Specifications
Background
GW2580 is a potent and selective, ATP-competitive inhibitor of cFMS kinase. It also inhibits macrophage-colony stimulating factor receptor, M-CSF/ CSF-1. cFMS is a type III receptor tyrosine kinase that binds to M-CSF or CSF-1. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states.
Product Name Alternative
5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine, 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine, GW 2580, GW-2580
UNSPSC
41116105
Source
Synthetic
Purity
≥98% (HPLC)
Weight
0.025
Format
White to beige solid
Solubility
Soluble in DMSO: 10 mg/ml, clear (warmed)
Molecular Formula
C20H22N4O3
Molecular Weight
366.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Conway J.G., et al. (2008) J. Pharm. Exp. Ther. 326(1): 41–50. 2. Conway J.G., et al. (2005) Pro. Nat. Acad. Sci. USA. 102(44): 16078–16083.
CAS Number
870483-87-7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
E04P0856-01 48 Well
Rabbit Pituitary specific positive transcription factor 1 (POU1F1) ELISA Kit
Ask
View Details 
E04P0856-02 96 Well
Rabbit Pituitary specific positive transcription factor 1 (POU1F1) ELISA Kit
Ask
View Details MBS6341885-01 0.2 mL
RHEBL1, NT (RHEBL1, GTPase RhebL1, Ras homolog enriched in brain like-1 c, Ras homolog enriched in brain-like protein 1, Rheb2) (APC)
Ask
View Details 
MBS6341885-02 5x 0.2 mL
RHEBL1, NT (RHEBL1, GTPase RhebL1, Ras homolog enriched in brain like-1 c, Ras homolog enriched in brain-like protein 1, Rheb2) (APC)
Ask
View Details 