GW2580
CFMS kinase inhibitor
Product Specifications
Background
GW2580 is a potent and selective, ATP-competitive inhibitor of cFMS kinase. It also inhibits macrophage-colony stimulating factor receptor, M-CSF/ CSF-1. cFMS is a type III receptor tyrosine kinase that binds to M-CSF or CSF-1. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states.
CAS Number
870483-87-7
Product Name Alternative
5-[[3-Methoxy-4-[ (4-methoxyphenyl) methoxy]phenyl]methyl]-2,4-Pyrimidinediamine, 5-[[3-Methoxy-4-[ (4-methoxyphenyl) methoxy]phenyl]methyl]pyrimidine-2,4-diamine, GW 2580, GW-2580
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
White to beige solid
Solubility
Soluble in DMSO: 10 mg/ml, clear (warmed)
Molecular Formula
C20H22N4O3
Molecular Weight
366.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Conway J.G., et al. (2008) J. Pharm. Exp. Ther. 326(1): 41–50. 2. Conway J.G., et al. (2005) Pro. Nat. Acad. Sci. USA. 102(44): 16078–16083.
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