GF109203X
PKC kinase inhibitor
Product Specifications
Background
GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.
CAS Number
133052-90-1
Product Name Alternative
2-[1- (3-Dimethylaminopropyl) indol-3-yl]-3- (indol-3-yl) maleimide, 3- (N-[Dimethylamino]propyl-3-indolyl) -4- (3-indolyl) maleimide, 3-[1-[3- (Dimethylamino) propyl]1H-indol-3-yl]-4- (1Hindol-3-yl) 1H-pyrrole-2,5dione, Bisindolylmaleimide I
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.001
Format
Red solid
Solubility
Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)
Molecular Formula
C25H24N4O2
Molecular Weight
412.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781.
2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.
3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.
4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.
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