CHIR99021
GSK3β kinase inhibitor
Product Specifications
Background
CHIR99021 is a potent and highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. It also promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization.
CAS Number
252917-06-9
Product Name Alternative
CT99021 , 6-[[2-[[4- (2,4-Dichlorophenyl) -5- (5-methyl-1H-imidazol-2-yl) -2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC) ; NMR (Conforms)
Weight
0.001
Format
White to light brown solid
Solubility
May be dissolved in DMSO (25mg/mL, warm)
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ye S., et al. (2012) PloS One 7(4): e35892. 2. Ring D. B., et al. (2003). Diabetes. 52(3): 588–595.
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