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BAY 11-7082

IKK kinase inhibitor

Product Specifications

Background

BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.

CAS Number

19542-67-7

Product Name Alternative

Bay 11-7821, (E) -3- (4-Methylphenylsulfonyl) -2-propenenitrile

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98% (HPLC)

Weight

0.01

Format

White solid

Solubility

Soluble to 25 mM in ethanol and to 100 mM in DMSO

Molecular Formula

C10H9NO2S

Molecular Weight

207.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.

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