BAY 11-7082
IKK kinase inhibitor
Product Specifications
Background
BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
CAS Number
19542-67-7
Product Name Alternative
Bay 11-7821, (E) -3- (4-Methylphenylsulfonyl) -2-propenenitrile
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.01
Format
White solid
Solubility
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Molecular Formula
C10H9NO2S
Molecular Weight
207.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
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