Alsterpaullone
CDK, GSK Inhibitor
Product Specifications
Background
Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.
CAS Number
237430-03-4
Product Name Alternative
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6 (5) -one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.005
Format
Yellow to brown powder
Solubility
Soluble in DMSO; insoluble in water or 100% ethanol
Molecular Formula
C16H11N3O3
Molecular Weight
293.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569.
2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.
3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.
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