Alsterpaullone

CDK, GSK Inhibitor

Product Specifications

Background

Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.

Product Name Alternative

9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (HPLC)

Weight

0.005

Format

Yellow to brown powder

Solubility

Soluble in DMSO; insoluble in water or 100% ethanol

Molecular Formula

C16H11N3O3

Molecular Weight

293.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569. 2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194. 3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.