AG 1478

EGFR kinase inhibitor

Product Specifications

Background

AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.

Product Name Alternative

N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine, 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline

UNSPSC

41116105

Source

Synthetic

Purity

≥98% (HPLC)

Weight

0.005

Format

White to light yellow solid

Solubility

Soluble in DMSO (10 mg/ml)

Molecular Formula

C16H14ClN3O2

Molecular Weight

315.8

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.