What is the catalog number for AG 1478?

The catalog number for AG 1478 is SIH-425-5MG.

What sizes are available for AG 1478?

AG 1478 is available in the following size(s): 5 mg.

AG 1478 is currently made to order / not held in immediate stock. Contact us for lead time.

AG 1478

EGFR kinase inhibitor

Product Specifications

Background

AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.

CAS Number

153436-53-4

Product Name Alternative

N- (3-Chlorophenyl) -6,7-dimethoxy-4-quinazolinamine, 4- (3-Chloroanilino) -6,7-dimethoxyquinazoline

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

≥98% (HPLC)

Weight

0.005

Format

White to light yellow solid

Solubility

Soluble in DMSO (10 mg/ml)

Molecular Formula

C16H14ClN3O2

Molecular Weight

315.8

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.