6BIO

PDK1 kinase inhibitor

Product Specifications

Background

6BIO is an inhibitor of phosphoinositide-dependent kinase 1 (PDK1), and a potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). It maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway.

CAS Number

667463-62-9

Product Name Alternative

(2'Z,3'E) -6-Bromoindirubin-3′-oxime, 6-BIO, 6BIO, (3Z) -6-Bromo-3-[ (3E) -3- (hydroxyimino) -1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling

Purity

≥98% (HPLC)

Weight

0.005

Format

Dark red solid

Solubility

Soluble to 10 mM in DMSO and to 10 mM in ethanol

Molecular Formula

C16H10BrN3O2

Molecular Weight

356.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Valerio A., et al. (2011) J. Neurochem. 116(6): 1148–1159. 2. Yasuhara R., et al. (2010) J. Biol. Chem. 285(1): 317–327. 3. Meijer L., et al. (2003) Chem. & Bio. 10(12): 1255–1266.