Niclosamide
Autophagy inducer
Product Specifications
Background
Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
CAS Number
50-65-7
Product Name Alternative
5-Chloro-N- (2-chloro-4-nitrophenyl) -2-hydroxybenzamide
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% (TLC) ; NMR (Conforms)
Weight
1
Format
Pale yellow solid
Solubility
Soluble to 25 mM in ethanol and to 10 mM in DMSO
Molecular Formula
C13H8Cl2N2O4
Molecular Weight
327.12
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.
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