Chloroquine diphosphate
Autophagy inhibitor
Product Specifications
Background
Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.
CAS Number
50-63-5
Product Name Alternative
N4- (7-Chloro-4-quinolinyl) -N1, N1-dimethyl-1,4-pentanediamine diphosphate salt
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
1
Format
Beige Solid
Solubility
May be dissolved in water (25mg/mL)
Molecular Formula
C18H26ClN3·2H3PO4
Molecular Weight
515.86
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.
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