Spautin-1
Autophagy inhibitor
Product Specifications
Background
Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
Product Name Alternative
6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
UNSPSC
41116105
Source
Synthetic
Purity
≥98% (TLC); NMR (Conforms)
Weight
0.005
Format
White to beige powder.
Solubility
May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm)
Molecular Formula
C15H11F2N3
Molecular Weight
271.26
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Liu J., et al. (2011) Cell. 147(1): 223-34.
CAS Number
1262888-28-7
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