Tunicamycin

Autophagy inducer

Product Specifications

Background

As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy (1-4). Triggers a-synuclein oligomerization, dopaminergic neurons death and locomotor impariement, potentially a model for Parkinson's Disease (5).

Product Name Alternative

Tunicamycin from Streptomyces sp.

UNSPSC

41116105

Source

Isolated from Streptomyces lysosuperficus

Purity

>98% (HPLC) as a mixture of tunicamycin A, B, C and D

Weight

0.005

Format

White solid.

Solubility

Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).

Molecular Formula

C39H64N4O16

Molecular Weight

844.95

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14. 2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10. 3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12. 4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35. 5. Coppola-Segovia V., et al. (2016) Molecular Neuro. 54, 5798-5806.