Rottlerin
Autophagy inducer
Product Specifications
Background
Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling. It is a neuroprotective in Parkinson's Disease models.
CAS Number
82-08-6
Product Name Alternative
3'-[ (8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl) methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease
Purity
≥98%
Weight
0.01
Format
Orange to brown solid.
Solubility
Soluble to 2 mM in ethanol and to 20 mM in DMSO.
Molecular Formula
C30H28O8
Molecular Weight
516.55
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8.
2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66.
3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92.
4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.
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