Rottlerin

Autophagy inducer

Product Specifications

Background

Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling. It is a neuroprotective in Parkinson's Disease models.

CAS Number

82-08-6

Product Name Alternative

3'-[ (8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl) methyl]-2',4',6'-trihydroxy-5'-methylacetophenone

UNSPSC

41116105

Type

Inducer

Source

Synthetic

Field of Research

Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease

Purity

≥98%

Weight

0.01

Format

Orange to brown solid.

Solubility

Soluble to 2 mM in ethanol and to 20 mM in DMSO.

Molecular Formula

C30H28O8

Molecular Weight

516.55

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8. 2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66. 3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92. 4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.