Wortmannin
Autophagy inhibitor
Product Specifications
Background
Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
CAS Number
19545-26-7
Product Name Alternative
SL-2052, KY12420
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
≥98%
Weight
0.005
Format
White to off-white solid.
Solubility
Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
Molecular Formula
C23H24O8
Molecular Weight
428.44
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23.
2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61.
3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4.
4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.
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