Bafilomycin A1
Autophagy inhibitor
Product Specifications
Background
Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.
CAS Number
88899-55-2
Product Name Alternative
(3Z,5E,7R,8S,9S,11E,13E,15S,16R) -8-Hydroxy-16-[ (1S,2R,3S) -2-hydroxy-1-methyl-3-[ (2R,4R,5S,6R) -tetrahydro-2,4-dihydroxy-5-methyl-6- (1-methylethyl) -2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% HPLC; NMR (Conforms)
Weight
0.0005
Format
White powder to colorless film.
Solubility
May be dissolved in DMSO (50mg/mL)
Molecular Formula
C35H58O9
Molecular Weight
622.84
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212.
2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.
3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.
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