Bafilomycin A1

Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.

(3Z,5E,7R,8S,9S,11E,13E,15S,16R) -8-Hydroxy-16-[ (1S,2R,3S) -2-hydroxy-1-methyl-3-[ (2R,4R,5S,6R) -tetrahydro-2,4-dihydroxy-5-methyl-6- (1-methylethyl) -2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

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