P32/98

DPPIV/DPP4 inhibitor

Product Specifications

Background

P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).

Product Name Alternative

3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.05

Format

White solid

Solubility

Soluble in water (20 mg/ml) or DMSO (25 mg/ml)

Molecular Formula

C9H18N2OS•0.5C4H4O4

Molecular Weight

260.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8. 3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94. 4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50. 5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.