P32/98
DPPIV/DPP4 inhibitor
Product Specifications
Background
P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).
CAS Number
136259-20-6
Product Name Alternative
3-N-[ ((2S,3S) -2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S) -2-Amino-3-methyl-1- (1,3-thiazolidin-3-yl) pentan-1-one fumarate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
>98%
Weight
0.01
Format
White solid
Solubility
Soluble in water (20 mg/ml) or DMSO (25 mg/ml)
Molecular Formula
C9H18N2OS•0.5C4H4O4
Molecular Weight
260.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11.
2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8.
3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94.
4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50.
5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83.
6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50.
7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11.
8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.
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