24(S)-Hydroxycholesterol

LXR ligand

Product Specifications

Background

Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.

Product Name Alternative

(3β,24S)-Cholest-5-ene-3,24-diol

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.005

Format

White solid

Solubility

Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).

Molecular Formula

C27H46O2

Molecular Weight

402.7

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Chawla A., et al. (2001) Science. 294(5548): 1866-70. 2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804. 3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5. 4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5. 5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.