24 (S) -Hydroxycholesterol
LXR ligand
Product Specifications
Background
Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.
CAS Number
474-73-7
Product Name Alternative
(3β,24S) -Cholest-5-ene-3,24-diol
UNSPSC
41116105
Type
Ligand
Source
Synthetic
Field of Research
Cell Signaling
Purity
>98%
Weight
0.005
Format
White solid
Solubility
Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).
Molecular Formula
C27H46O2
Molecular Weight
402.7
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Chawla A., et al. (2001) Science. 294(5548): 1866-70.
2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.
3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.
4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.
5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.
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