6-Formylindolo[3,2-b]carbazole (FICZ)
Ah receptor ligand
Product Specifications
Background
A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7x10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.
CAS Number
172922-91-7
Product Name Alternative
Indolo[3,2-b]carbazole-6-carbaldehyde, FICZ
UNSPSC
41116105
Type
Ligand
Source
Synthetic
Field of Research
Cell Signaling
Purity
>95%
Weight
0.0005
Format
Yellow solid
Solubility
Soluble in DMSO (10 mg/ml)
Molecular Formula
C19H12N2O
Molecular Weight
284.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55.
2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855.
3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
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