6-Formylindolo[3,2-b]carbazole (FICZ)

Ah receptor ligand

Product Specifications

Background

A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7x10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.

CAS Number

172922-91-7

Product Name Alternative

Indolo[3,2-b]carbazole-6-carbaldehyde, FICZ

UNSPSC

41116105

Type

Ligand

Source

Synthetic

Field of Research

Cell Signaling

Purity

>95%

Weight

0.0005

Format

Yellow solid

Solubility

Soluble in DMSO (10 mg/ml)

Molecular Formula

C19H12N2O

Molecular Weight

284.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55. 2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855. 3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.