Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Calhex 231 (hydrochloride)

Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca2+-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) [1].

Product Specifications

CAS Number

2387505-78-2

UNSPSC

12352005

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/calhex-231-hydrochloride.html

Purity

99.81

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H]1[C@@H](N[C@@H](C2=C3C=CC=CC3=CC=C2)C)CCCC1)C4=CC=C(Cl)C=C4.[H]Cl

Molecular Formula

C25H28Cl2N2O

Molecular Weight

443.41

References & Citations

[1]Christophe Petrel, et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca (2+) -sensing receptor. J Biol Chem. 2003 Dec 5;278 (49) :49487-94.|[2]Petrel C1, et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca (2+) -sensing receptor. J Biol Chem. 2003 Dec 5;278 (49) :49487-94.|[3]Yan Lei, et al. The Calcilytic Drug Calhex-231 Ameliorates Vascular Hyporesponsiveness in Traumatic Hemorrhagic Shock by Inhibiting Oxidative Stress and miR-208a-Mediated Mitochondrial Fission. Oxid Med Cell Longev. 2020 Dec 3:2020:4132785.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Food Chem. 2024 Jul 6:459:140359.|Front Pharmacol. 2022 Feb 23:13:816133.|Front Pharmacol. 2022 Feb 23;13:816133.|J Funct Foods. 2025 Apr.|Mol Nutr Food Res. 2024 Feb;68 (4) :e2200726.|Eur J Pharmacol. 2024 Jul 31:980:176828.|J Nat Med. 2025 Sep;79 (5) :1154-1166.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Lumichrome-d8
TRC-L473852-1MG 1 mg

Lumichrome-d8

Sign In for Pricing
View Details
BSDC1 Antibody
KC-42619-01 50 μL

BSDC1 Antibody

Sign In for Pricing
View Details
BSDC1 Antibody
KC-42619-02 100 µL

BSDC1 Antibody

Sign In for Pricing
View Details
BSDC1 Antibody
KC-42619-03 1 mL

BSDC1 Antibody

Sign In for Pricing
View Details
C14orf68 (SLC25A47) Human Gene Knockout Kit (CRISPR)
KN421734 1 Kit

C14orf68 (SLC25A47) Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Mouse Crh activation kit by CRISPRa
GA200871 1 Kit

Mouse Crh activation kit by CRISPRa

Sign In for Pricing
View Details