SP600125

Jnk inhibitor

Product Specifications

Background

Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.

Product Name Alternative

Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.05

Format

Yellow to brown solid

Solubility

Soluble in DMSO or methanol

Molecular Formula

C14H8N2O

Molecular Weight

220.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.