SP600125
Jnk inhibitor
Product Specifications
Background
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.
CAS Number
129-56-6
Product Name Alternative
Anthra (1,9-cd) pyrazol-6 (2H) -one, 1,9-Pyrazoloanthrone
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis
Purity
>98%
Weight
0.01
Format
Yellow to brown solid
Solubility
Soluble in DMSO or methanol
Molecular Formula
C14H8N2O
Molecular Weight
220.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6.
2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63.
3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204.
4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.
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