DAPT
γ-secretase inhibitor
Product Specifications
Background
Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
CAS Number
208255-80-5
Product Name Alternative
N-[ (3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Cell Signaling | Neuroscience | Neurodegeneration | Amyloid
Purity
>99%
Weight
0.025
Format
White to off-white powder
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C23H26F2N2O4
Molecular Weight
432.46
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81.
2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.
3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.
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